Rngtt CLIA Kit for Mouse(Mus musculus) | EIAab.comRngtt CLIA Kit for Mouse(Mus musculus)

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Index > Protein center > Rngtt(Gene name) > Mouse

Rngtt (Gene name),

mRNA-capping enzyme (Protein name ), MCE1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Rngtt(Cap1a);

Protein name:

mRNA-capping enzyme;

Alternative:

MCE1;HCE;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with SUPT5H and RNMT.

Function:

Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

597

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

597:

NPVTKEMLFE | FIDRCAAAAQ | GQKRKYPLDP | DTELMPPPPP | KRLHRPT

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

mmu:24018

String:

O55236

SMR:

O55236

UniGene:

Mm.240024

Pfam:

PF00782

Uniprot:

O55236

FOR

ELISA Kit for Mouse mRNA-capping enzyme

Cat.:

E15262h

Price:

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MSDS:

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Packing:

96T

ELISA Kit for Mouse mRNA-capping enzyme

Cat.:

E15262m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse mRNA-capping enzyme

Cat.:

U15262h

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MSDS:

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Packing:

96T

CLIA Kit for Mouse mRNA-capping enzyme

Cat.:

U15262m

Price:

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MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Mouse mRNA-capping enzyme

Cat.:

P15262Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse mRNA-capping enzyme

Cat.:

P15262Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse mRNA-capping enzyme

Protein for Mouse mRNA-capping enzyme

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Mammalian capping enzyme complements mutant Saccharomyces cerevisiae lacking mRNA guanylyltransferase and selectively binds the elongating form of RNA polymerase II."
Yue Z. , Maldonado E. , Pillutla R. , Cho H. , Reinberg D. , Shatkin A.J.
Proc. Natl. Acad. Sci. U.S.A.94:12898-12903(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];MUTAGENESIS OF LYS-294;FUNCTION;SUBUNIT
2.

"5'-Capping enzymes are targeted to pre-mRNA by binding to the phosphorylated carboxy-terminal domain of RNA polymerase II."
McCracken S. , Fong N. , Rosonina E. , Yankulov K. , Brothers G. , Siderovski D. , Hessel A. , Foster S. , Shuman S. , Bentley D.L.
Genes Dev.11:3306-3318(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];SUBUNIT
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: FVB/N.
tissue: Mammary gland.
4.

"Mammalian capping enzyme binds RNA and uses protein tyrosine phosphatase mechanism."
Wen Y. , Yue Z. , Shatkin A.J.
Proc. Natl. Acad. Sci. U.S.A.95:12226-12231(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION;MUTAGENESIS
5.

"Structure and mechanism of the RNA triphosphatase component of mammalian mRNA capping enzyme."
Changela A. , Ho C.K. , Martins A. , Shuman S. , Mondragon A.
EMBO J.20:2575-2586(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS)
6.

"Structural insights to how mammalian capping enzyme reads the CTD code."
Ghosh A. , Shuman S. , Lima C.D.
Mol. Cell43:299-310(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.81 ANGSTROMS) OF 226-567 IN COMPLEX WITH GUANINE AND POLR2A PEPTIDE;INTERACTION WITH POLR2A;CATALYTIC ACTIVITY;FUNCTION;MUTAGENESIS OF CYS-375

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